Please use this identifier to cite or link to this item:
Title: Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways.
Authors: Olmedo, Dionisio A
López-Pérez, José Luis
Del Olmo, Esther
Bedoya, Luis M
Sancho, Rocío
Alcamí, José
Muñoz, Eduardo
Feliciano, Arturo San
Gupta, Mahabir P
Keywords: 4-phenyl-chromen-one;AIDS;NF-κB inhibition;Tat protein;anti-HIV activity;neoflavonoids
metadata.dc.subject.mesh: Anti-HIV Agents
HIV Infections
Microbial Sensitivity Tests
Molecular Structure
NF-kappa B
Signal Transduction
Virus Replication
tat Gene Products, Human Immunodeficiency Virus
Issue Date: 19-Feb-2017
Abstract: Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations
metadata.dc.identifier.doi: 10.3390/molecules22020321
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC6155902.pdf793,53 kBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons