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Title: The utility of the macro-aggregated albumin lung perfusion scan in the diagnosis and prognosis of hepatopulmonary syndrome in cirrhotic patients candidates for liver transplantation.
Authors: Grilo, Israel
Pascasio, Juan Manuel
Tirado, Juan Luis
López-Pardo, Francisco-Jesús
Ortega-Ruiz, Francisco
Sousa, José Manuel
Rodríguez-Puras, María José
Ferrer, María Teresa
Gómez-Bravo, Miguel Ángel
Grilo Reina, Antonio
metadata.dc.subject.mesh: Adult
Follow-Up Studies
Hepatopulmonary Syndrome
Liver Cirrhosis
Liver Transplantation
Middle Aged
Organotechnetium Compounds
Preoperative Care
Prospective Studies
Radionuclide Imaging
Sensitivity and Specificity
Severity of Illness Index
Survival Rate
Issue Date: 2017
Abstract: The macro-aggregated albumin lung perfusion scan (99mTc-MAA) is a diagnostic method for hepatopulmonary syndrome (HPS). To determine the sensitivity of 99mTc-MAA in diagnosing HPS, to establish the utility of 99mTc-MAA in determining the influence of HPS on hypoxemia in patients with concomitant pulmonary disease and to determine the correlation between 99mTc-MAA values and other respiratory parameters. Data from 115 cirrhotic patients who were eligible for liver transplantation (LT) were prospectively analyzed. A transthoracic contrast echocardiography and 99mTc-MAA were performed in 85 patients, and 74 patients were diagnosed with HPS. The overall sensitivity of 99mTc-MAA for the diagnosis of HPS was 18.9% (14/74) in all of the HPS cases and 66.7% (4/6) in the severe to very severe cases. In HPS patients who did not have lung disease, the degree of brain uptake of 99mTc-MAA was correlated with the alveolar-arterial oxygen gradient (A-a PO2) (r = 0.32, p The 99mTc-MAA is a low sensitivity test for the diagnosis of HPS that can be useful in patients who have concomitant lung disease and in severe to very severe cases of HPS. It was not related to mortality, and brain uptake normalized after LT.
metadata.dc.identifier.doi: 10.17235/reed.2017.4219/2016
ISSN: 1130-0108
Appears in Collections:Producción 2020

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