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Title: Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption.
Authors: González, Ana
Gálvez, Natividad
Martín, Jesús
Reyes, Fernando
Pérez-Victoria, Ignacio
Dominguez-Vera, Jose M
Keywords: Iron metabolism;Iron supplement;Lactobacillus fermentum;Probiotic bacteria
metadata.dc.subject.mesh: Fermentation
Limosilactobacillus fermentum
Issue Date: 4-Feb-2017
Abstract: We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic acid (HPLA). Reduction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract. By reducing Fe(III), HPLA boosts Fe(II) absorption through the DMT1 channels of enterocytes. An in vitro experiment tested and confirmed this hypothesis. This discovery opens new avenues for the treatment of iron deficiency in humans, one of the most common and widespread nutritional disorders in the world.
metadata.dc.identifier.doi: 10.1016/j.foodchem.2017.02.008
Appears in Collections:Producción 2020

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