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Title: Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms
Authors: Cruz-Merino, Luis de la
Henao Carrasco, Fernando
Vicente Baz, David
Nogales Fernández, Esteban
Reina Zoilo, Juan José
Codes Manuel de Villena, Manuel
Grande Pulido, Enrique
metadata.dc.contributor.authoraffiliation: [Cruz-Merino, L de la ; Henao Carrasco, F; Vicente Baz, D; Nogales Fernández, E; Reina Zoilo, JJ; Codes Manuel de Villena, M] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Grande Pulido, E] Clinical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Keywords: Antígenos CD80;Antineoplásicos;Antígeno CTLA-4;Neoplasias Colorrectales;Pronóstico;Linfocitos T Reguladores
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::B7 Antigens::Antigens, CD80
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Costimulatory and Inhibitory T-Cell Receptors::CTLA-4 Antigen
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma
Medical Subject Headings::Diseases::Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocytes, Tumor-Infiltrating
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Genomic Instability::Microsatellite Instability
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxic
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets::T-Lymphocytes, Regulatory
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Tumor Markers, Biological
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Medical Subject Headings::Anatomy::Cells::Antigen-Presenting Cells
Issue Date: 2011
Publisher: Hindawi Publishing Corporation
Citation: Cruz-Merino L de la, Henao Carrasco F, Vicente Baz D, Nogales Fernández E, Reina Zoilo JJ, Codes Manuel de Villena M, et al. Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin. Dev. Immunol.; 2011:174149
Abstract: Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.
Description: Journal Article; Review;
metadata.dc.identifier.doi: 10.1155/2011/174149
ISSN: 1740-2530 (Online)
1740-2522 (Print)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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