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http://hdl.handle.net/10668/1098| Title: | Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms |
| Authors: | Cruz-Merino, Luis de la Henao Carrasco, Fernando Vicente Baz, David Nogales Fernández, Esteban Reina Zoilo, Juan José Codes Manuel de Villena, Manuel Grande Pulido, Enrique |
| metadata.dc.contributor.authoraffiliation: | [Cruz-Merino, L de la ; Henao Carrasco, F; Vicente Baz, D; Nogales Fernández, E; Reina Zoilo, JJ; Codes Manuel de Villena, M] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Grande Pulido, E] Clinical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. |
| Keywords: | Antígenos CD80;Antineoplásicos;Antígeno CTLA-4;Neoplasias Colorrectales;Pronóstico;Linfocitos T Reguladores |
| metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::B7 Antigens::Antigens, CD80 Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Costimulatory and Inhibitory T-Cell Receptors::CTLA-4 Antigen Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma Medical Subject Headings::Diseases::Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocytes, Tumor-Infiltrating Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Genomic Instability::Microsatellite Instability Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Cytokine-Induced Killer Cells::T-Lymphocytes, Cytotoxic Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets::T-Lymphocytes, Regulatory Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Tumor Markers, Biological Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment Medical Subject Headings::Anatomy::Cells::Antigen-Presenting Cells |
| Issue Date: | 2011 |
| Publisher: | Hindawi Publishing Corporation |
| Citation: | Cruz-Merino L de la, Henao Carrasco F, Vicente Baz D, Nogales Fernández E, Reina Zoilo JJ, Codes Manuel de Villena M, et al. Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin. Dev. Immunol.; 2011:174149 |
| Abstract: | Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells. |
| Description: | Journal Article; Review; |
| URI: | http://hdl.handle.net/10668/1098 |
| metadata.dc.relation.publisherversion: | http://www.hindawi.com/journals/cdi/2011/174149/abs/ |
| metadata.dc.identifier.doi: | 10.1155/2011/174149 |
| ISSN: | 1740-2530 (Online) 1740-2522 (Print) |
| Appears in Collections: | 01- Artículos - Hospital Virgen Macarena |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Cruz-MerinoL_Immune Microenvironment in Colorectal Cancer.pdf | Revisión | 701,58 kB | Adobe PDF | View/Open |
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