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Title: Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype.
Authors: Huertas, Ismael
Jesús, Silvia
Lojo, José Antonio
García-Gómez, Francisco Javier
Cáceres-Redondo, María Teresa
Oropesa-Ruiz, Juan Manuel
Carrillo, Fátima
Vargas-Gonzalez, Laura
Martín Rodríguez, Juan Francisco
Gómez-Garre, Pilar
García-Solís, David
Mir, Pablo
metadata.dc.subject.mesh: Adult
Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Middle Aged
Molecular Imaging
Neuropsychological Tests
Parkinson Disease
Postural Balance
Uric Acid
Issue Date: 30-Mar-2017
Abstract: Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability. We included 75 PD patients from whom we collected information about their motor symptoms, DAT imaging and UA concentration levels. Based on the predominance of their motor symptoms, patients were classified into postural instability and gait disorder (PIGD, n = 36), intermediate (I, n = 22), and tremor-dominant (TD, n = 17) subtypes. The levels of UA and striatal DAT were compared across subtypes and the correlation between these two measures was also explored. We found that PIGD patients had lower levels of UA (3.7 vs 4.5 vs 5.3 mg/dL; P
metadata.dc.identifier.doi: 10.1371/journal.pone.0174644
Appears in Collections:Producción 2020

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