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Title: Novel miRNA-mRNA interactions conserved in essential cancer pathways.
Authors: Andrés-León, Eduardo
Cases, Ildefonso
Alonso, Sergio
Rojas, Ana M
metadata.dc.subject.mesh: Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Proportional Hazards Models
RNA, Messenger
Signal Transduction
Statistics as Topic
Survival Analysis
Issue Date: 7-Apr-2017
Abstract: Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy.
metadata.dc.identifier.doi: 10.1038/srep46101
Appears in Collections:Producción 2020

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