Por favor, usa este identificador para citar o enlazar este ítem: http://hdl.handle.net/10668/11078
Título : [Aetiology, outcomes and prognostic indicators of paediatric acute liver failure].
Otros títulos : Etiología, resultados e indicadores pronósticos del fallo hepático agudo pediátrico.
Autor : Gilbert Pérez, Juan José
Jordano Moreno, Belén
Rodríguez Salas, Mónica
Palabras clave : Acute liver failure;Children;Fallo hepático agudo;Niños;PELD
MeSH: Adolescent
Child, Preschool
Liver Failure, Acute
Liver Transplantation
Retrospective Studies
Treatment Outcome
Fecha de publicación : 8-abr-2017
Abstract: Acute liver failure (ALF) is a multisystem disease with severe impairment of liver function of acute onset. The Paediatric End-stage Liver Disease (PELD) score is used as a predictor of mortality in chronic liver disease, however experience is limited in ALF. To evaluate the aetiology and outcomes of children with ALF in a Children's Liver Transplant Centre, and to investigate the validity of PELD as a prognostic indicator. A retrospective study was conducted on patients diagnosed with ALF in our hospital from 2000 to 2013 using the criteria of the Paediatric ALF Study Group. The study included 49 patients with an age range 0-14years. The most frequent aetiologies were: indeterminate (36.7%) and metabolic (26.5%). Liver transplant (LT) was required by 42.8%, and there were 16.3% deaths. Patients with higher levels of bilirubin, INR, or encephalopathy were more likely to require a liver transplant, yielding an OR for INR 1.93. A cut-off of 27 in the PELD score according to the ROC curve showed a sensitivity of 86% and a specificity of 85%, predicting a worse outcome (AUC: 0.90; P ALF patients with a high PELD score and the presence of encephalopathy had worse outcomes. The PELD score could be a useful tool to establish the optimum time for inclusion in the transplant list, however further studies are still needed.
URI: http://hdl.handle.net/10668/11078
DOI: 10.1016/j.anpedi.2017.02.017
Aparece en las colecciones: Producción 2020

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