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Title: Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body.
Authors: Annese, Valentina
Navarro-Guerrero, Elena
Rodríguez-Prieto, Ismael
Pardal, Ricardo
Keywords: angiogenesis and neurogenesis;carotid body physiology;hypoxia;neural-crest-derived adult stem cell plasticity and multipotency
metadata.dc.subject.mesh: Adult Stem Cells
Blood Vessels
Carotid Body
Cell Differentiation
Cell Hypoxia
Endothelial Cells
Hypoxia-Inducible Factor 1, alpha Subunit
Mice, Transgenic
Multipotent Stem Cells
Neovascularization, Physiologic
Neural Stem Cells
Neuronal Plasticity
Issue Date: 2017
Abstract: Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxia-released vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy.
metadata.dc.identifier.doi: 10.1016/j.celrep.2017.03.065
Appears in Collections:Producción 2020

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