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Title: Is the bronchodilator test an useful tool to measure asthma control?
Authors: Ferrer Galván, Marta
Javier Alvarez Gutiérrez, Francisco
Romero Falcón, Auxiliadora
Romero Romero, Beatriz
Sáez, Antonia
Medina Gallardo, Juan Francisco
Keywords: Asthma control;FEV(1) reversibility;Future risk
metadata.dc.subject.mesh: Adult
Bronchial Provocation Tests
Bronchodilator Agents
Disease Management
Forced Expiratory Volume
Middle Aged
Nitric Oxide
Predictive Value of Tests
Prospective Studies
Risk Assessment
Issue Date: 12-Mar-2017
Abstract: Asthma control includes the control of symptoms and future risk. We sought to evaluate the usefulness of the degree of spirometric reversibility of the forced expiratory volume in one second (FEV1) as the target parameter of control. Patients with bronchial asthma were followed up for one year. The clinical, functional, inflammatory and control parameters of the asthma were collected. The area under the curve (AUC) was estimated to establish the cutoff point of the post-bronchodilator FEV1 reversibility in relation to non-control asthma. In the univariate analysis, the differences between groups were studied based on the degree of estimated reversibility. Factors with a significance A total of 407 patients with a mean age of 38.1 ± 16.7 years were included. When the patients were grouped into controlled and non-controlled groups, compared with post-bronchodilator FEV1 reversibility, the cutoff point obtained for the non-controlled group was ≥10% (sensitivity: 65.8%, specificity: 48.4%, positive predictive value: 69.5%, and AUC: 0.619 [0.533-0.700], p  Spirometric reversibility can be useful in assessing control in asthmatic patients and can predict future risk parameters. The cutoff point related to the non-control of asthma found in our work was ≥10%.
metadata.dc.identifier.doi: 10.1016/j.rmed.2017.03.008
Appears in Collections:Producción 2020

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