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dc.contributor.authorArenas de Larriva, Antonio P
dc.contributor.authorNorby, Faye L
dc.contributor.authorChen, Lin Y
dc.contributor.authorSoliman, Elsayed Z
dc.contributor.authorHoogeveen, Ron C
dc.contributor.authorArking, Dan E
dc.contributor.authorLoehr, Laura R
dc.contributor.authorAlonso, Alvaro
dc.description.abstractCeruloplasmin (CP) may promote structural changes in the atrium making it more arrhythmogenic. We assessed the associations between CP, CP-associated genetic variants, and incident atrial fibrillation (AF) in the Atherosclerosis Risk in Communities (ARIC) study. We studied 10,059 men and women without prevalent AF aged 53 to 75years in 1996-1998 and followed through 2012. Circulating CP was measured in stored blood samples obtained in 1996-1998. Polymorphisms rs11708215 and rs13072552, previously associated with CP concentrations, were measured in 10,059 and 8829 participants respectively. AF was ascertained from study electrocardiograms, hospital discharge codes, and death certificates. Multivariable Cox models were run to study the association between circulating CP, CP-associated polymorphisms, and the incidence of AF. Over 10.5years of mean follow-up, 1357 cases of AF were identified. After adjusting for traditional risk factors and biomarkers, higher levels of circulating CP were associated with incident AF (hazard ratio [HR] 1.33, 95% confidence interval [CI] 1.11, 1.61 comparing top to bottom quartiles). Both rs11708215 and rs13072552 were significantly associated with CP levels. Presence of the CP-increasing alleles in rs11708215 and rs13072552, however, were significantly associated with lower risk of AF in whites (HR 0.84, 95%CI 0.76, 0.94, p=0.002 and HR 0.83; 95%CI 0.69, 0.99, p=0.043 respectively per CP-increasing allele in the final adjusted model) but not in African Americans. Even though higher CP concentrations were associated with increased AF risk, genetic variants associated with higher CP decreased the risk of AF in whites. Our results suggest that circulating CP levels may not be causally related to risk of incident AF.
dc.subjectAtrial fibrillation
dc.subjectOxidative stress
dc.subjectSingle nucleotide polymorphism
dc.subject.meshAtrial Fibrillation
dc.subject.meshGenetic Association Studies
dc.subject.meshIndependent Living
dc.subject.meshMiddle Aged
dc.titleCirculating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.
dc.typeresearch article
dc.rights.accessRightsopen access
dc.journal.titleInternational journal of cardiology
dc.journal.titleabbreviationInt J Cardiol
dc.organizationHospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.pubmedtypeJournal Article
Appears in Collections:Producción 2020

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