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Title: Overproduction of Outer Membrane Protein A by Acinetobacter baumannii as a Risk Factor for Nosocomial Pneumonia, Bacteremia, and Mortality Rate Increase.
Authors: Sánchez-Encinales, Viviana
Álvarez-Marín, Rocío
Pachón-Ibáñez, María Eugenia
Fernández-Cuenca, Felipe
Pascual, Alvaro
Garnacho-Montero, José
Martínez-Martínez, Luis
Vila, Jordi
Tomás, María Mar
Cisneros, José Miguel
Bou, Germán
Rodríguez-Baño, Jesús
Pachón, Jerónimo
Smani, Younes
Keywords: Acinetobacter baumannii;bacteremia;mortality;pneumonia;OmpA
metadata.dc.subject.mesh: Acinetobacter baumannii
Aged, 80 and over
Bacterial Outer Membrane Proteins
Cross Infection
Disease Models, Animal
Mice, Inbred C57BL
Microbial Sensitivity Tests
Middle Aged
Multivariate Analysis
Pneumonia, Bacterial
Risk Factors
Severity of Illness Index
Young Adult
Issue Date: 2017
Abstract: Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort. Representative isolates were classified into 2 groups: (1) isolates from patients colonized by A. baumannii (16 from the unicenter and 20 from the multicenter cohort) and (2) isolates from bacteremic or nonbacteremic patients with pneumonia (PP) caused by A. baumannii (13 from the unicenter and 23 from the multicenter cohort) Expression of ompA was determined with quantitative reverse-transcription polymerase chain reaction. Isolates from PP overexpressed more ompA than those from colonized patients from the unicenter (ratio, 1.76 vs 0.36; P These data suggest that ompA overexpression is an associated factor for pneumonia, bacteremia, and death due to A. baumannii.
metadata.dc.identifier.doi: 10.1093/infdis/jix010
Appears in Collections:Producción 2020

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