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Title: Spontaneous clearance of chronic hepatitis C is rare in HIV-infected patients after effective use of combination antiretroviral therapy.
Authors: Frias, Mario
Rivero-Juarez, Antonio
Tellez, Francisco
Perez-Perez, Monserrat
Camacho, Angela
Machuca, Isabel
Lorenzo-Moncada, Sandra
Lopez-Lopez, Pedro
Rivero, Antonio
Grupo de Estudio de Hepatitis Virales (HEPAVIR) of the Sociedad Andaluza de Enfermedades Infecciosas (SAEI)
metadata.dc.subject.mesh: Adult
Anti-HIV Agents
HIV Infections
Hepatitis C, Chronic
Remission Induction
Retrospective Studies
Young Adult
Issue Date: 4-May-2017
Abstract: To evaluate the rate of spontaneous resolution of chronic hepatitis C (CHC) infection in a cohort of HIV-infected patients. A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months. Of 509 patients, 3 (0.59%; 95% CI: 0.15%-1.6%) experienced spontaneous clearance of CHC. After combination antiretroviral therapy (cART) initiation, two of three cases experienced an increased CD4+ count, coinciding with HCV viral clearance. All patients were IL28B CC carriers, 2 were co-infected with HCV genotype 3 (the HCV genotype of the remaining patient was not available). Spontaneous clearance of CHC is a rare event in the context of HIV/HCV co-infected patients and may be associated with the effective use of cART and thus HIV suppression.
metadata.dc.identifier.doi: 10.1371/journal.pone.0177141
Appears in Collections:Producción 2020

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