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Title: Early Acquisition of Pneumocystis jirovecii Colonization and Potential Association With Respiratory Distress Syndrome in Preterm Newborn Infants.
Authors: Rojas, Pilar
Friaza, Vicente
García, Elisa
de la Horra, Carmen
Vargas, Sergio L
Calderón, Enrique J
Pavón, Antonio
Keywords: pneumocystis;preterm infants;respiratory distress syndrome
metadata.dc.subject.mesh: Birth Weight
Carrier State
DNA, Fungal
Gestational Age
Infant, Newborn
Infant, Premature
Pneumocystis carinii
Pneumonia, Pneumocystis
Prospective Studies
Respiratory Distress Syndrome, Newborn
Issue Date: 2017
Abstract: Pneumocystis pneumonia is a well-recognized lung disease of premature and malnourished babies. Even though serologic studies have shown that children are exposed to Pneumocystis jirovecii early in life, the epidemiology of human P. jirovecii infection and the host-microorganism relationship in infancy remain poorly understood. The aim of the present study was to investigate the prevalence of P. jirovecii colonization in preterm infants and its possible association with medical complications. A prospective observational study of preterm infants (birth weight A total of 128 preterm infants were included during the study period. Pneumocystis DNA was identified in 25.7% (95% confidence interval [CI], 17.8%-33.7%) of newborns studied. A significant increase of respiratory distress syndrome in colonized group, even after adjusting for confounding factors (odds ratio, 2.7 [95% CI, 1.0-7.5]; P = .04), was observed. No differences were observed in other medical conditions between the 2 groups. Pneumocystis jirovecii colonization is frequent in preterm births and could be a risk factor to develop respiratory distress syndrome among preterm infants.
metadata.dc.identifier.doi: 10.1093/cid/cix454
Appears in Collections:Instituto de Investigación Biomédica de Sevilla (IBIS)
SAS - Hospital Universitario Virgen del Rocío

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