RISalud
Institutional Health Repository of Andalucía
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10668/11237| Title: | Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study. |
| Authors: | Duell, Eric J Lujan-Barroso, Leila Sala, Núria Deitz McElyea, Samantha Overvad, Kim Tjonneland, Anne Olsen, Anja Weiderpass, Elisabete Busund, Lill-Tove Moi, Line Muller, David Vineis, Paolo Aune, Dagfinn Matullo, Giuseppe Naccarati, Alessio Panico, Salvatore Tagliabue, Giovanna Tumino, Rosario Palli, Domenico Kaaks, Rudolf Katzke, Verena A Boeing, Heiner Bueno-de-Mesquita, H B As Peeters, Petra H Trichopoulou, Antonia Lagiou, Pagona Kotanidou, Anastasia Travis, Ruth C Wareham, Nick Khaw, Kay-Tee Ramon Quiros, Jose Rodríguez-Barranco, Miguel Dorronsoro, Miren Chirlaque, María-Dolores Ardanaz, Eva Severi, Gianluca Boutron-Ruault, Marie-Christine Rebours, Vinciane Brennan, Paul Gunter, Marc Scelo, Ghislaine Cote, Greg Sherman, Stuart Korc, Murray |
| Keywords: | biomarkers;cohort studies;microRNAs;pancreatic cancer |
| metadata.dc.subject.mesh: | Adult Aged Area Under Curve Biomarkers, Tumor Carcinoma, Pancreatic Ductal Case-Control Studies Female Humans Male MicroRNAs Middle Aged Pancreatic Neoplasms Polymerase Chain Reaction Prospective Studies ROC Curve Sensitivity and Specificity |
| Issue Date: | 12-Jun-2017 |
| Abstract: | Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection. MiR levels in prediagnostic plasma samples were determined by quantitative RT-PCR. Logistic regression was used to model levels and PDAC risk, adjusting for covariates and to estimate area under the receiver operating characteristic curves (AUC). Plasma miR-10b, -21-5p, -30c and -106b levels were significantly higher in cases diagnosed within 2 years of blood collection compared to matched controls (all p-values |
| URI: | http://hdl.handle.net/10668/11237 |
| metadata.dc.identifier.doi: | 10.1002/ijc.30790 |
| Appears in Collections: | Producción 2020 |
Files in This Item:
There are no files associated with this item.
This item is protected by original copyright |
Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.