Please use this identifier to cite or link to this item:
Title: Treatment of NAFLD with diet, physical activity and exercise.
Authors: Romero-Gómez, Manuel
Zelber-Sagi, Shira
Trenell, Michael
Keywords: Behaviour intervention;Exercise;Fibrosis;Mediterranean diet;Physical activity;Steatohepatitis;Steatosis;Weight loss
metadata.dc.subject.mesh: Behavior Therapy
Caloric Restriction
Carcinoma, Hepatocellular
Clinical Trials as Topic
Diet, Mediterranean
Life Style
Liver Neoplasms
Non-alcoholic Fatty Liver Disease
Risk Factors
Risk Reduction Behavior
Sedentary Behavior
Weight Loss
Issue Date: 23-May-2017
Abstract: Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases (NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also regress liver disease. Weight reductions of ⩾10% can induce a near universal non-alcoholic steatohepatitis resolution and fibrosis improvement by at least one stage. However, modest weight loss (>5%) can also produce important benefits on the components of the NAFLD activity score (NAS). Additionally, we need to explore the role of total calories and type of weight loss diet, micro- and macronutrients, evidence-based benefits of physical activity and exercise and finally support these modifications through established behavioural change models and techniques for long-term maintenance of lifestyle modifications. Following a Mediterranean diet can reduce liver fat even without weight loss and is the most recommended dietary pattern for NAFLD. The Mediterranean diet is characterised by reduced carbohydrate intake, especially sugars and refined carbohydrates (40% of the calories vs. 50-60% in a typical low fat diet), and increased monounsaturated and omega-3 fatty acid intake (40% of the calories as fat vs. up-to 30% in a typical low fat diet). Both TV sitting (a reliable marker of overall sedentary behaviour) and physical activity are associated with cardio-metabolic health, NAFLD and overall mortality. A 'triple hit behavioural phenotype' of: i) sedentary behaviour, ii) low physical activity, and iii) poor diet have been defined. Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH. This should be accompanied by the implementation of strategies to avoid relapse and weight regain.
metadata.dc.identifier.doi: 10.1016/j.jhep.2017.05.016
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.