Please use this identifier to cite or link to this item:
Title: Cholesterol and stroke: Roll of PCSK9 inhibitors.
Other Titles: Colesterol e ictus: papel de los inhibidores de la proproteína convertasa subtilisina/kexina tipo 9.
Authors: Castilla-Guerra, L
Fernández-Moreno, M C
Rico-Corral, M A
Keywords: Cholesterol;Colesterol;Ictus;Inhibidores de PCSK9;LDL;PCSK9 inhibitors;Prevención;Prevention;Pro-protein convertase subtilisin kexine type 9;Proproteína convertasa subtilisina kexina tipo 9;Stroke
metadata.dc.subject.mesh: Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Anticholesteremic Agents
Cholesterol, LDL
PCSK9 Inhibitors
Proprotein Convertase 9
Receptors, LDL
Issue Date: 24-May-2017
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the modulation of plasma levels of low density lipoprotein cholesterol (LDLC). PCSK9 binds to the LDL receptor (LDLR), disrupts its endocytic recycling itinerary and directs it to lysosomal degradation. Activation of PCSK9 can thus decrease the expression of LDLR in the liver and inhibit LDL uptake, which leads to hypercholesterolaemia. Currently we now know that different polymorphisms of PCSK9 are associated with the occurrence of ischaemic stroke. On the other hand, PCSK9 inhibitors prevent binding of PCSK9 to LDLR and inhibit degradation of LDLR, which results in increased hepatic uptake of LDL and lower LDL levels in blood. Different phase 2 and 3 studies, including OSLER and ODYSSEY LONG-TERM, have demonstrated the efficacy and safety of the new monoclonal antibodies against PCSK9 such as evolucumab and alirocumab, and the first exploratory analyses have shown evidence of their efficacy in decreasing vascular events, including stroke. Although few strokes have been reported by these studies, new ongoing trials examining the cardiovascular effects of evolucumab (FOURIER study), alirocumab (ODYSSEY OUTCOMES study), and bococizumab (SPIRE-1 and SPIRE-2 studies) will reveal the true potential of these drugs, particularly for the prevention of stroke.
metadata.dc.identifier.doi: 10.1016/j.nrl.2017.03.009
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons