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Title: Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Authors: Stepien, Magdalena
Jenab, Mazda
Freisling, Heinz
Becker, Niels-Peter
Czuban, Magdalena
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Boutron-Ruault, Marie-Christine
Mancini, Francesca Romana
Savoye, Isabelle
Katzke, Verena
Kühn, Tilman
Boeing, Heiner
Iqbal, Khalid
Trichopoulou, Antonia
Bamia, Christina
Orfanos, Philippos
Palli, Domenico
Sieri, Sabina
Tumino, Rosario
Naccarati, Alessio
Panico, Salvatore
Bueno-de-Mesquita, H B As
Peeters, Petra H
Weiderpass, Elisabete
Merino, Susana
Jakszyn, Paula
Sanchez, Maria-Jose
Dorronsoro, Miren
Huerta, José María
Barricarte, Aurelio
Boden, Stina
van Guelpen, Behany
Wareham, Nick
Khaw, Kay-Tee
Bradbury, Kathryn E
Cross, Amanda J
Schomburg, Lutz
Hughes, David J
metadata.dc.subject.mesh: Aged
Biomarkers, Tumor
Case-Control Studies
Colorectal Neoplasms
Middle Aged
Oxidative Stress
Prospective Studies
Risk Factors
White People
Issue Date: 2017
Abstract: Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
metadata.dc.identifier.doi: 10.1093/carcin/bgx051
Appears in Collections:Producción 2020

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