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http://hdl.handle.net/10668/11274| Title: | Efficacy of β-Lactam/β-Lactamase Inhibitor Combinations for the Treatment of Bloodstream Infection Due to Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in Hematological Patients with Neutropenia. |
| Authors: | Gudiol, Carlota Royo-Cebrecos, Cristina Abdala, Edson Akova, Murat Álvarez, Rocío Maestro-de la Calle, Guillermo Cano, Angela Cervera, Carlos Clemente, Wanessa T Martín-Dávila, Pilar Freifeld, Alison Gómez, Lucía Gottlieb, Thomas Gurguí, Mercè Herrera, Fabián Manzur, Adriana Maschmeyer, Georg Meije, Yolanda Montejo, Miguel Peghin, Maddalena Rodríguez-Baño, Jesús Ruiz-Camps, Isabel Sukiennik, Teresa C Tebe, Cristian Carratalà, Jordi BICAR Study Group |
| Keywords: | ESBLs;beta-lactam/beta-lactamase inhibitors;bloodstream infection;mortality;neutropenia |
| metadata.dc.subject.mesh: | Adult Anti-Bacterial Agents Bacteremia Carbapenems Cohort Studies Enterobacteriaceae Enterobacteriaceae Infections Female Humans Male Middle Aged Neutropenia beta-Lactamase Inhibitors beta-Lactamases beta-Lactams |
| Issue Date: | 25-Jul-2017 |
| Abstract: | β-Lactam/β-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum-β-lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem-sparing alternatives for the treatment of BSI due to ESBLs in these patients. |
| URI: | http://hdl.handle.net/10668/11274 |
| metadata.dc.identifier.doi: | 10.1128/AAC.00164-17 |
| Appears in Collections: | Producción 2020 |
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