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Title: Circulating antioxidant defences are decreased in healthy people after a high-fat meal.
Authors: Cardona, Fernando
Túnez, Isaac
Tasset, Inmaculada
Garrido-Sánchez, Lourdes
Collantes, Eduardo
Tinahones, Francisco José
metadata.dc.contributor.authoraffiliation: [Cardona,F; Garrido-Sánchez,L; Tinahones,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Cardona,F; Garrido-Sánchez,L; Tinahones,FJ] CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Málaga, Spain. [Túnez,I; Tasset,I] Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain. [Collantes,E] Servicio de Reumatología, Hospital Universitario Reina Sofía de Córdoba. Departamento de Medicina, Universidad de Córdoba, Córdoba, Spain.
Keywords: Uric acid;Oxidative Stress;Postprandial hyperlipidaemia;High-fat meal;Antioxidantes;HDL-Colesterol;Grasas en la Dieta;Peroxidación de Lípido;Triglicéridos
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL
Medical Subject Headings::Chemicals and Drugs::Lipids::Fats::Dietary Fats
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipid Peroxidation
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Postprandial Period
Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerides
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Xanthines::Uric Acid
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: Aug-2008
Publisher: Cambridge University Press
Citation: Cardona F, Túnez I, Tasset I, Garrido-Sánchez L, Collantes E, Tinahones FJ. Circulating antioxidant defences are decreased in healthy people after a high-fat meal. Br. J. Nutr. 2008; 100(2):312-6
Abstract: The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
Description: Journal Article; The research group belongs to the ‘Centros de Investigación en Red’ (CIBER, CB06/03/0018) of the Instituto de Salud Carlos III, SAF 2006/12 894 of the MCYT, Madrid, Spain.
metadata.dc.identifier.doi: 10.1017/S0007114507894347
ISSN: 1475-2662 (Online)
0007-1145 (Print)
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen de la Victoria

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