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Title: Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals.
Authors: Rivera, Margarita
Locke, Adam E
Corre, Tanguy
Czamara, Darina
Wolf, Christiane
Ching-Lopez, Ana
Milaneschi, Yuri
Kloiber, Stefan
Cohen-Woods, Sarah
Rucker, James
Aitchison, Katherine J
Bergmann, Sven
Boomsma, Dorret I
Craddock, Nick
Gill, Michael
Holsboer, Florian
Hottenga, Jouke-Jan
Korszun, Ania
Kutalik, Zoltan
Lucae, Susanne
Maier, Wolfgang
Mors, Ole
Müller-Myhsok, Bertram
Owen, Michael J
Penninx, Brenda W J H
Preisig, Martin
Rice, John
Rietschel, Marcella
Tozzi, Federica
Uher, Rudolf
Vollenweider, Peter
Waeber, Gerard
Willemsen, Gonneke
Craig, Ian W
Farmer, Anne E
Lewis, Cathryn M
Breen, Gerome
McGuffin, Peter
metadata.dc.subject.mesh: Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Body Mass Index
Case-Control Studies
Depressive Disorder, Major
Genetic Predisposition to Disease
Polymorphism, Genetic
Issue Date: 22-Jun-2017
Abstract: BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.ResultsIn the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × 10-4) and with the Han/Eskin random effects method (P = 1.4 × 10-7) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10-8). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTOConclusionsThis meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
metadata.dc.identifier.doi: 10.1192/bjp.bp.116.183475
Appears in Collections:Producción 2020

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