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Title: Increased blood levels of transforming growth factor β in patients with aortic dilatation.
Authors: Rueda-Martínez, Carmen
Lamas, Oscar
Carrasco-Chinchilla, Fernando
Robledo-Carmona, Juan
Porras, Carlos
Sánchez-Espín, Gemma
Navarro, Manuel Jiménez
Fernández, Borja
Keywords: Aortic dilatation;Bicuspid aortic valve;Biomarker;TGF-β
metadata.dc.subject.mesh: Aged
Aortic Aneurysm, Thoracic
Aortic Valve
Bicuspid Aortic Valve Disease
Cardiac Surgical Procedures
Heart Valve Diseases
Middle Aged
Transforming Growth Factor beta1
Issue Date: 2017
Abstract: Recent studies have shown that patients with syndromic thoracic aortic aneurysm, particularly patients with bicuspid aortic valve, have increased blood levels of transforming growth factor β1 (TGF-β1), indicating this molecule as a prognostic biomarker. However, it is not known whether TGF-β1 is also elevated in the blood of patients with tricuspid aortic valve and aortic dilatation. We analysed the plasma levels of TGF-β1 in 52 patients with tricuspid or bicuspid aortic valve and with normal or dilated ascending aorta who underwent cardiac surgery in our hospital. TGF-β1 blood level was significantly increased two-fold in patients with tricuspid aortic valve and dilated aorta compared to patients with tricuspid aortic valve and normal aorta. Our results suggest that TGF-β1 blood levels may serve as a prognostic biomarker for patients with syndromic and non-syndromic thoracic aortic aneurysm. Further studies with larger cohorts of patients should be performed to confirm these results.
metadata.dc.identifier.doi: 10.1093/icvts/ivx153
Appears in Collections:Producción 2020

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