Please use this identifier to cite or link to this item:
Title: Strategies to Reduce Oxidative Stress in Glaucoma Patients.
Authors: Pinazo-Duran, Maria D
Shoaie-Nia, Kian
Zanon-Moreno, Vicente
Sanz-Gonzalez, Silva M
Del Castillo, Javier Benitez
Garcia-Medina, Jose J
Keywords: Glaucoma;antioxidants;essential fatty acids;natural compounds;nitrosative stress;oxidative stress.
metadata.dc.subject.mesh: Animals
Oxidative Stress
Issue Date: 2018
Abstract: Primary open-angle glaucoma (POAG) is a multifactorial pathology involving a variety of pathogenic mechanisms, including oxidative/nitrosative stress. This latter is the consequence of the imbalance between excessive formation and insufficient protection against reactive oxygen/nitrogen species. Our main goal is to gather molecular information to better managing pathologic variants that may determine the individual susceptibility to oxidative/nitrosative stress (OS/NS) and POAG. An extensive search of the scientific literature was conducted using PUBMED, the Web of Science, the Cochrane Library, and other references on the topic of POAG and OS/NS from human and animal model studies published between 2010 and 2017. Finally, 152 works containing relevant information that may help understanding the role of antioxidants, essential fatty acids, natural compounds and other similar strategies for counteracting OS/NS in POAG were considered. A wide variety of studies have proven that antioxidants, among them vitamins B3, C and E, Coenzyme Q10 or melatonin, ω-3/ω-6 fatty acids and other natural compounds (such as coffee, green tea, bear bile, gingko biloba, coleus, tropical fruits, etc.,) may help regulating the intraocular pressure as well as protecting the retinal neurons against OS/NS in POAG. Based on the impact of antioxidants and ω-3/ω-6 fatty acids at the molecular level in the glaucomatous anterior and posterior eye segments, further studies are needed by integrating all issues involved in glaucoma pathogenesis, endogenous and exogenous risk factors and their interactions that will allow us to reach newer effective biotherapies for preventing glaucomatous irreversible blindness.
metadata.dc.identifier.doi: 10.2174/1570159X15666170705101910
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC6120109.pdf1,35 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons