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Title: Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.
Authors: Pérez-Sánchez, Carlos
Aguirre, María Ángeles
Ruiz-Limón, Patricia
Ábalos-Aguilera, María Carmen
Jiménez-Gómez, Yolanda
Arias-de la Rosa, Iván
Rodriguez-Ariza, Antonio
Fernández-Del Río, Lucía
González-Reyes, José Antonio
Segui, Pedro
Collantes-Estévez, Eduardo
Barbarroja, Nuria
Velasco, Francisco
Sciascia, Savino
Cecchi, Irene
Cuadrado, María José
Villalba, José Manuel
López-Pedrera, Chary
Keywords: antiphospholipid syndrome;extracellular traps;inflammation;oxidative stress;thrombosis;ubiquinol
metadata.dc.subject.mesh: Antiphospholipid Syndrome
Cross-Over Studies
Endothelium, Vascular
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Middle Aged
Prospective Studies
Issue Date: 6-Jul-2017
Abstract: Antiphospholipid syndrome (APS) leukocytes exhibit an oxidative perturbation, directly linked to alterations in mitochondrial dynamics and metabolism. This disturbance is related to the patients' prothrombotic status and can be prevented by in vitro treatment with coenzyme Q10. Our aim was to investigate short-term effects of in vivo ubiquinol (reduced coenzyme Q10 [Qred]) supplementation on markers related to inflammation and thrombosis in APS through a prospective, randomized, crossover, placebo-controlled trial. Thirty-six patients with APS were randomized to receive Qred (200 mg/d) or placebo for 1 month. Thirty-three patients with APS completed the intervention, which increased plasma coenzyme Q10. Qred improved endothelial function and decreased monocyte expression of prothrombotic and proinflammatory mediators, inhibited phosphorylation of thrombosis-related protein kinases, and decreased peroxides and percentage of monocytes with depolarized mitochondria; mitochondrial size was increased, and mitochondrial biogenesis-related genes were upregulated. Qred ameliorated extruded neutrophil extracellular traps in neutrophils and downregulated peroxides, intracellular elastase, and myeloperoxidase. Nanostring microRNA profiling revealed 20 microRNAs reduced in APS monocytes, and 16 of them, with a preponderance of cardiovascular disease-related target mRNAs, were upregulated. Monocytes gene profiling showed differential expression of 29 atherosclerosis-related genes, 23 of them changed by Qred. Interaction networks of genes and microRNAs were identified. Correlation studies demonstrated co-ordinated effects of Qred on thrombosis and endothelial function-associated molecules. Our results highlight the potential of Qred to modulate the overexpression of inflammatory and thrombotic risk markers in APS. Because of the absence of clinically significant side effects and its potential therapeutic benefits, Qred might act as safe adjunct to standard therapies in APS. URL: Unique identifier: NCT02218476.
metadata.dc.identifier.doi: 10.1161/ATVBAHA.117.309225
Appears in Collections:Producción 2020

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