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dc.contributor.authorSuberviola, Borja
dc.contributor.authorRellan, Luzdivina
dc.contributor.authorRiera, Jordi
dc.contributor.authorIranzo, Reyes
dc.contributor.authorGarcia Campos, Ascension
dc.contributor.authorRobles, Juan Carlos
dc.contributor.authorVicente, Rosario
dc.contributor.authorMiñambres, Eduardo
dc.contributor.authorSantibanez, Miguel
dc.description.abstractInfections and primary graft dysfunction are devastating complications in the immediate postoperative period following lung transplantation. Nowadays, reliable diagnostic tools are not available. Biomarkers could improve early infection diagnosis. Multicentre prospective observational study that included all centres authorized to perform lung transplantation in Spain. Lung infection and/or primary graft dysfunction presentation during study period (first postoperative week) was determined. Biomarkers were measured on ICU admission and daily till ICU discharge or for the following 6 consecutive postoperative days. We included 233 patients. Median PCT levels were significantly lower in patients with no infection than in patients with Infection on all follow up days. PCT levels were similar for PGD grades 1 and 2 and increased significantly in grade 3. CRP levels were similar in all groups, and no significant differences were observed at any study time point. In the absence of PGD grade 3, PCT levels above median (0.50 ng/ml on admission or 1.17 ng/ml on day 1) were significantly associated with more than two- and three-fold increase in the risk of infection (adjusted Odds Ratio 2.37, 95% confidence interval 1.06 to 5.30 and 3.44, 95% confidence interval 1.52 to 7.78, respectively). In the absence of severe primary graft dysfunction, procalcitonin can be useful in detecting infections during the first postoperative week. PGD grade 3 significantly increases PCT levels and interferes with the capacity of PCT as a marker of infection. PCT was superior to CRP in the diagnosis of infection during the study period.
dc.rightsAttribution 4.0 International
dc.subject.meshCommunicable Diseases
dc.subject.meshEarly Diagnosis
dc.subject.meshLung Transplantation
dc.subject.meshMiddle Aged
dc.subject.meshPostoperative Complications
dc.subject.meshPrimary Graft Dysfunction
dc.subject.meshProspective Studies
dc.titleRole of biomarkers in early infectious complications after lung transplantation.
dc.typeresearch article
dc.rights.accessRightsopen access
dc.journal.titlePloS one
dc.journal.titleabbreviationPLoS One
dc.organizationServicio Andaluz de Salud-SAS
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeObservational Study
Appears in Collections:Producción 2020

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