| Title: | Transancestral mapping and genetic load in systemic lupus erythematosus. |
| Authors: | Langefeld, Carl D
Ainsworth, Hannah C
Cunninghame Graham, Deborah S
Kelly, Jennifer A
Comeau, Mary E
Marion, Miranda C
Howard, Timothy D
Ramos, Paula S
Croker, Jennifer A
Morris, David L
Sandling, Johanna K
Almlöf, Jonas Carlsson
Acevedo-Vásquez, Eduardo M
Alarcón, Graciela S
Babini, Alejandra M
Baca, Vicente
Bengtsson, Anders A
Berbotto, Guillermo A
Bijl, Marc
Brown, Elizabeth E
Brunner, Hermine I
Cardiel, Mario H
Catoggio, Luis
Cervera, Ricard
Cucho-Venegas, Jorge M
Dahlqvist, Solbritt Rantapää
D'Alfonso, Sandra
Da Silva, Berta Martins
de la Rúa Figueroa, Iñigo
Doria, Andrea
Edberg, Jeffrey C
Endreffy, Emőke
Esquivel-Valerio, Jorge A
Fortin, Paul R
Freedman, Barry I
Frostegård, Johan
García, Mercedes A
de la Torre, Ignacio García
Gilkeson, Gary S
Gladman, Dafna D
Gunnarsson, Iva
Guthridge, Joel M
Huggins, Jennifer L
James, Judith A
Kallenberg, Cees G M
Kamen, Diane L
Karp, David R
Kaufman, Kenneth M
Kottyan, Leah C
Kovács, László
Laustrup, Helle
Lauwerys, Bernard R
Li, Quan-Zhen
Maradiaga-Ceceña, Marco A
Martín, Javier
McCune, Joseph M
McWilliams, David R
Merrill, Joan T
Miranda, Pedro
Moctezuma, José F
Nath, Swapan K
Niewold, Timothy B
Orozco, Lorena
Ortego-Centeno, Norberto
Petri, Michelle
Pineau, Christian A
Pons-Estel, Bernardo A
Pope, Janet
Raj, Prithvi
Ramsey-Goldman, Rosalind
Reveille, John D
Russell, Laurie P
Sabio, José M
Aguilar-Salinas, Carlos A
Scherbarth, Hugo R
Scorza, Raffaella
Seldin, Michael F
Sjöwall, Christopher
Svenungsson, Elisabet
Thompson, Susan D
Toloza, Sergio M A
Truedsson, Lennart
Tusié-Luna, Teresa
Vasconcelos, Carlos
Vilá, Luis M
Wallace, Daniel J
Weisman, Michael H
Wither, Joan E
Bhangale, Tushar
Oksenberg, Jorge R
Rioux, John D
Gregersen, Peter K
Syvänen, Ann-Christine
Rönnblom, Lars
Criswell, Lindsey A
Jacob, Chaim O
Sivils, Kathy L
Tsao, Betty P
Schanberg, Laura E
Behrens, Timothy W
Silverman, Earl D
Alarcón-Riquelme, Marta E
Kimberly, Robert P
Harley, John B
Wakeland, Edward K
Graham, Robert R
Gaffney, Patrick M
Vyse, Timothy J |
| metadata.dc.subject.mesh: | Age of Onset
American Indian or Alaska Native
Black People
Case-Control Studies
Genetic Load
HLA Antigens
Hispanic or Latino
Humans
Logistic Models
Lupus Erythematosus, Systemic
Multifactorial Inheritance
Mutagenesis, Insertional
Polymorphism, Single Nucleotide
Sequence Deletion
White People |
| Issue Date: | 17-Jul-2017 |
| Abstract: | Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P |
| URI: | http://hdl.handle.net/10668/11414 |
| metadata.dc.identifier.doi: | 10.1038/ncomms16021 |
| Appears in Collections: | Producción 2020
|
