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Title: The Combined Intervention with Germinated Vigna radiata and Aerobic Interval Training Protocol Is an Effective Strategy for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Alterations Related to the Metabolic Syndrome in Zucker Rats.
Authors: Kapravelou, Garyfallia
Martínez, Rosario
Nebot, Elena
López-Jurado, María
Aranda, Pilar
Arrebola, Francisco
Cantarero, Samuel
Galisteo, Milagros
Porres, Jesus M
Keywords: Vigna radiata;aerobic interval training;diet;exercise;germination;legume protein hydrolyzate;liver histology;metabolic syndrome;non-alcoholic fatty liver disease;obesity
metadata.dc.subject.mesh: Alanine Transaminase
Alkaline Phosphatase
Aspartate Aminotransferases
Blood Glucose
Disease Models, Animal
Insulin Resistance
Lipid Metabolism
Metabolic Syndrome
Non-alcoholic Fatty Liver Disease
Oxygen Consumption
Physical Conditioning, Animal
Plant Preparations
Rats, Zucker
Issue Date: 19-Jul-2017
Abstract: Metabolic syndrome (MetS) is a group of related metabolic alterations that increase the risk of developing non-alcoholic fatty liver disease (NAFLD). Several lifestyle interventions based on dietary treatment with functional ingredients and physical activity are being studied as alternative or reinforcement treatments to the pharmacological ones actually in use. In the present experiment, the combined treatment with mung bean (Vigna radiata), a widely used legume with promising nutritional and health benefits that was included in the experimental diet as raw or 4 day-germinated seed flour, and aerobic interval training protocol (65-85% VO₂ max) has been tested in lean and obese Zucker rats following a 2 × 2 × 2 (2 phenotypes, 2 dietary interventions, 2 lifestyles) factorial ANOVA (Analysis of Variance) statistical analysis. Germination of V. radiata over a period of four days originated a significant protein hydrolysis leading to the appearance of low molecular weight peptides. The combination of 4 day-germinated V. radiata and aerobic interval training was more efficient compared to raw V. radiata at improving the aerobic capacity and physical performance, hepatic histology and functionality, and plasma lipid parameters as well as reverting the insulin resistance characteristic of the obese Zucker rat model. In conclusion, the joint intervention with legume sprouts and aerobic interval training protocol is an efficient treatment to improve the alterations of glucose and lipid metabolism as well as hepatic histology and functionality related to the development of NAFLD and the MetS.
metadata.dc.identifier.doi: 10.3390/nu9070774
Appears in Collections:Producción 2020

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