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Title: Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment.
Authors: Pinto-Medel, María Jesús
Oliver-Martos, Begoña
Urbaneja-Romero, Patricia
Hurtado-Guerrero, Isaac
Ortega-Pinazo, Jesús
Serrano-Castro, Pedro
Fernández, Óscar
Leyva, Laura
metadata.dc.subject.mesh: Adult
Case-Control Studies
DNA Methylation
Disease Susceptibility
Logistic Models
Long Interspersed Nucleotide Elements
Multiple Sclerosis
Multivariate Analysis
ROC Curve
Reference Standards
Issue Date: 18-Aug-2017
Abstract: The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis (MS) patients and healthy controls. In addition, we assessed the association of LINE-1 methylation with clinical disease activity in patients treated with IFNbeta (IFNβ). We found that individuals with high levels of LINE-1 methylation showed 6-fold increased risk of suffering MS. Additionally, treated MS patients who bear high LINE-1 methylation levels had an 11-fold increased risk of clinical activity. Moreover, a negative correlation between treatment duration and percentage of LINE-1 methylation, that was statistically significant exclusively in the group of patients without clinical activity, was observed. Our data suggest that in MS patients, a slight global DNA hypermethylation occurs that may be related to the pathophysiology of the disease. In addition, global DNA methylation levels could play a role as a biomarker for the differential clinical response to IFNβ.
metadata.dc.identifier.doi: 10.1038/s41598-017-09301-2
Appears in Collections:Producción 2020

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