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Title: Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study.
Authors: Fernández de Larrea-Baz, Nerea
Pérez-Gómez, Beatriz
Michel, Angelika
Romero, Beatriz
Lope, Virginia
Pawlita, Michael
Fernández-Villa, Tania
Moreno, Victor
Martín, Vicente
Willhauck-Fleckenstein, Martina
López-Abente, Gonzalo
Castilla, Jesús
Fernández-Tardón, Guillermo
Dierssen-Sotos, Trinidad
Santibáñez, Miguel
Peiró, Rosana
Jiménez-Moleón, José Juan
Navarro, Carmen
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Pollán, Marina
de Sanjosé, Silvia
Del Campo, Rosa
Waterboer, Tim
Aragonés, Nuria
Keywords: Biomarkers;Case-control studies;Gastric neoplasm;Helicobacter pylori infection;Multiplex serology
metadata.dc.subject.mesh: Aged
Antigens, Bacterial
Bacterial Proteins
Biomarkers, Tumor
Case-Control Studies
Helicobacter Infections
Helicobacter pylori
Logistic Models
Middle Aged
Risk Factors
Seroepidemiologic Studies
Stomach Neoplasms
Issue Date: 7-Sep-2017
Abstract: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against≥4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cagδ was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cagδ maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk.
metadata.dc.identifier.doi: 10.1016/j.canep.2017.08.002
Appears in Collections:Producción 2020

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