Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain.

Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/11577

Title:	Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain.
Authors:	van der Meer, Thomas P Artacho-Cordón, Francisco Swaab, Dick F Struik, Dicky Makris, Konstantinos C Wolffenbuttel, Bruce H R Frederiksen, Hanne van Vliet-Ostaptchouk, Jana V
Keywords:	bisphenol-A;brain;hypothalamus;methylparaben;obesity;parabens;phenols
metadata.dc.subject.mesh:	Adult Brain Chromatography, Liquid Endocrine Disruptors Environmental Exposure Environmental Pollutants Female Humans Male Obesity Pilot Projects Tandem Mass Spectrometry
Issue Date:	13-Sep-2017
Abstract:	Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI 30 and BMI
URI:	http://hdl.handle.net/10668/11577
metadata.dc.identifier.doi:	10.3390/ijerph14091059
Appears in Collections:	Producción 2020

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