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Title: Prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients.
Authors: Torres, E
López-Cerero, L
Morales, I
Navarro, M D
Rodríguez-Baño, J
Pascual, A
Keywords: Escherichia coli;Horizontal transmission;Intestinal carriage;Intestinal persistence;ST131
metadata.dc.subject.mesh: Community-Acquired Infections
Cross Infection
Drug Resistance, Multiple, Bacterial
Escherichia coli
Escherichia coli Infections
Longitudinal Studies
Microbial Sensitivity Tests
Urinary Tract Infections
Issue Date: 19-Sep-2017
Abstract: The Escherichia coli O25b-associated ST131 clonal group was recently found to be prevalent in our area as a cause of community-acquired urinary tract infections. We evaluated the transmission dynamics and longitudinal persistence of E. coli O25b-ST131 between patients with nosocomial and community-acquired infections and their contacts. Prevalence and transmission of O25b/pabB3/B23 isolates were compared in 38 community clusters, 30 nosocomial clusters and 50 healthy volunteers. Duration of colonization was studied at 1 to 4 months and 6 to 12 months after the first sample. Isolates exhibiting a three-band or less difference by pulsed-field gel electrophoresis were assigned to the same pulsotype. Colonization was found to be more frequent in index cases (31/68, 45.6%) than in contacts (25/118, 21.2%; p 0.0009) or volunteers (1/50, 2%; p 0.0009). Seven (11%) of 64 isolates were extended-spectrum β-lactamase producers. Transmission occurred in 61% (8/13) community clusters and in 12% (1/8) nosocomial clusters. Thirteen (56.5%) of the 23 initial carriers assessed at 1 to 4 months remained colonized. Only 2 (13.3%) of 15 positive patients followed for 6 to 12 months showed prolonged carriage, and none was infected with extended-spectrum β-lactamase producers. Six previously positive individuals acquired a different ST131 pulsotype (5/23 at sample 2 and 1/15 at sample 3), and three previously negative individuals became positive (2/46 at 1-4 months and 1/33 at 6-12 months). Person-to-person transmission or acquisition from a common source of E. coli O25b-associated ST131 is more frequent in the household setting than in the nosocomial setting. The carrier state does not usually last beyond 4 months, with new acquisitions in certain individuals.
metadata.dc.identifier.doi: 10.1016/j.cmi.2017.09.007
Appears in Collections:Producción 2020

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