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Title: Malignant bone tumors (other than Ewing's): clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS).
Authors: Redondo, Andrés
Bagué, Silvia
Bernabeu, Daniel
Ortiz-Cruz, Eduardo
Valverde, Claudia
Alvarez, Rosa
Martinez-Trufero, Javier
Lopez-Martin, Jose A
Correa, Raquel
Cruz, Josefina
Lopez-Pousa, Antonio
Santos, Aurelio
García Del Muro, Xavier
Martin-Broto, Javier
Keywords: Bone sarcomas;Bone tumors;Clinical guideline;Diagnosis;Treatment
metadata.dc.subject.mesh: Biomedical Research
Bone Neoplasms
Follow-Up Studies
Hispanic or Latino
Issue Date: 16-Oct-2017
Abstract: Primary malignant bone tumors are uncommon and heterogeneous malignancies. This document is a guideline developed by the Spanish Group for Research on Sarcoma with the participation of different specialists involved in the diagnosis and treatment of bone sarcomas. The aim is to provide practical recommendations with the intention of helping in the clinical decision-making process. The diagnosis and treatment of bone tumors requires a multidisciplinary approach, involving as a minimum pathologists, radiologists, surgeons, and radiation and medical oncologists. Early referral to a specialist center could improve patients' survival. The multidisciplinary management of osteosarcoma, chondrosarcoma, chordoma, giant cell tumor of bone and other rare bone tumors is reviewed in this guideline. Ewing's sarcoma will be the focus of a separate guideline because of its specific biological, clinical and therapeutic features. Each statement has been accompanied by the level of evidence and grade of recommendation on the basis of the available data. Surgical excision is the mainstay of treatment of a localized bone tumor, with various techniques available depending on the histologic type, grade and location of the tumor. Chemotherapy plays an important role in some chemosensitive subtypes (such as high-grade osteosarcoma). In other subtypes, historically considered chemoresistant (such as chordoma or giant cell tumor of bone), new targeted therapies have emerged recently, with a very significant efficacy in the case of denosumab. Radiation therapy is usually necessary in the treatment of chordoma and sometimes of other bone tumors.
metadata.dc.identifier.doi: 10.1007/s00280-017-3436-0
Appears in Collections:Producción 2020

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