Please use this identifier to cite or link to this item:
Title: Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.
Authors: Milaneschi, Yuri
Lamers, Femke
Peyrot, Wouter J
Baune, Bernhard T
Breen, Gerome
Dehghan, Abbas
Forstner, Andreas J
Grabe, Hans J
Homuth, Georg
Kan, Carol
Lewis, Cathryn
Mullins, Niamh
Nauck, Matthias
Pistis, Giorgio
Preisig, Martin
Rivera, Margarita
Rietschel, Marcella
Streit, Fabian
Strohmaier, Jana
Teumer, Alexander
Van der Auwera, Sandra
Wray, Naomi R
Boomsma, Dorret I
Penninx, Brenda W J H
CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
metadata.dc.subject.mesh: Adult
Body Mass Index
C-Reactive Protein
Depressive Disorder, Major
Diagnostic and Statistical Manual of Mental Disorders
Genetic Predisposition to Disease
Genome-Wide Association Study
International Cooperation
Psychiatric Status Rating Scales
Weight Gain
Issue Date: 2017
Abstract: The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin). This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of the Psychiatric Genomics Consortium. Data sets were drawn from case-control, cohort, and population-based studies, including 26 628 participants with established psychiatric diagnoses and genome-wide genotype data. Data on BMI were available for 15 237 participants. Data were retrieved and analyzed from September 28, 2015, through May 20, 2017. Lifetime DSM-IV MDD was diagnosed using structured diagnostic instruments. Patients with MDD were stratified into subgroups according to change in the DSM-IV A/W symptoms as decreased or increased. Data included 11 837 participants with MDD and 14 791 control individuals, for a total of 26 628 participants (59.1% female and 40.9% male). Among participants with MDD, 5347 (45.2%) were classified in the decreased A/W and 1871 (15.8%) in the increased A/W subgroups. Common genetic variants explained approximately 10% of the heritability in the 2 subgroups. The increased A/W subgroup showed a strong and positive genetic correlation (SE) with BMI (0.53 [0.15]; P = 6.3 × 10-4), whereas the decreased A/W subgroup showed an inverse correlation (-0.28 [0.14]; P = .06). Furthermore, the decreased A/W subgroup had a higher polygenic risk for increased BMI (odds ratio [OR], 1.18; 95% CI, 1.12-1.25; P = 1.6 × 10-10) and levels of CRP (OR, 1.08; 95% CI, 1.02-1.13; P = 7.3 × 10-3) and leptin (OR, 1.09; 95% CI, 1.06-1.12; P = 1.7 × 10-3). The phenotypic associations between atypical depressive symptoms and obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD. Development of treatments effectively targeting immunometabolic dysregulations may benefit patients with depression and obesity, both syndromes with important disability.
metadata.dc.identifier.doi: 10.1001/jamapsychiatry.2017.3016
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.