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Title: The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis.
Authors: Alonso-Molero, Jéssica
González-Donquiles, Carmen
Palazuelos, Camilo
Fernández-Villa, Tania
Ramos, Elena
Pollán, Marina
Aragonés, Nuria
Llorca, Javier
Henar Alonso, M
Tardón, Adonina
Amiano, Pilar
Moleon, José Juan Jiménez
Pérez, Rosana Peiró
Capelo, Rocío
Molina, Antonio J
Acebo, Inés Gómez
Guevara, Marcela
Perez-Gomez, Beatriz
Lope, Virginia
Huerta, José María
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Moreno, Victor
Martín, Vicente
Keywords: Colorectal cancer;Gene-environment;Mediterranean diet;SMAD7;rs4939827
metadata.dc.subject.mesh: Adult
Aged, 80 and over
Case-Control Studies
Colorectal Neoplasms
Diet, Mediterranean
Gene-Environment Interaction
Genetic Association Studies
Genetic Predisposition to Disease
Middle Aged
Polymorphism, Single Nucleotide
Smad7 Protein
Young Adult
Issue Date: 30-Oct-2017
Abstract: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. We examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008-2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype. High adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors. The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- β pathway in this cancer.
metadata.dc.identifier.doi: 10.1186/s12881-017-0485-5
Appears in Collections:Producción 2020

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