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http://hdl.handle.net/10668/11760| Title: | Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis. |
| Authors: | Sánchez, Elena García de la Torre, Ignacio Sacnún, Mónica Goñi, Mario Berbotto, Guillermo Paira, Sergio Musuruana, Jorge Luis Graf, César Alvarellos, Alejandro Messina, Osvaldo D Babini, Alejandra Strusberg, Ingrid Marcos, Juan Carlos Scherbarth, Hugo Spindler, Alberto Quinteros, Ana Toloza, Sergio Moreno, José Luis C Catoggio, Luis J Tate, Guillermo Eimon, Alicia Citera, Gustavo Pellet, Antonio Catalán Nasswetter, Gustavo Cardiel, Mario H Miranda, Pedro Ballesteros, Francisco Esquivel-Valerio, Jorge A Maradiaga-Ceceña, Marco A Acevedo-Vásquez, Eduardo M García, Conrado García Tusié-Luna, Teresa Pons-Estel, Bernardo A Alarcón-Riquelme, Marta E GENAR Study |
| Keywords: | ADMIXTURE;AMERINDIAN;LATIN AMERICAN;RHEUMATOID ARTHRITIS;SMOKING |
| metadata.dc.subject.mesh: | Adult Age Factors Aged Alleles Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Argentina Arthritis, Rheumatoid Chile Female Genotype Humans Indians, North American Indians, South American Isoxazoles Leflunomide Male Methotrexate Mexico Middle Aged Peru Radiography Rheumatoid Factor Sex Factors Sulfasalazine |
| Issue Date: | 1-Nov-2017 |
| Abstract: | To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles. |
| URI: | http://hdl.handle.net/10668/11760 |
| metadata.dc.identifier.doi: | 10.3899/jrheum.160485 |
| ISSN: | 0315-162X |
| Appears in Collections: | Producción 2020 |
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