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Title: High adherence to the Western, Prudent, and Mediterranean dietary patterns and risk of gastric adenocarcinoma: MCC-Spain study.
Authors: Castelló, Adela
Fernández de Larrea, Nerea
Martín, Vicente
Dávila-Batista, Verónica
Boldo, Elena
Guevara, Marcela
Moreno, Víctor
Castaño-Vinyals, Gemma
Gómez-Acebo, Inés
Fernández-Tardón, Guillermo
Peiró, Rosana
Olmedo-Requena, Rocío
Capelo, Rocio
Navarro, Carmen
Pacho-Valbuena, Silvino
Pérez-Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Aragonés, Nuria
MCC-Spain researchers
Keywords: Adenocarcinoma;Diet, Mediterranean;Diet, Western;Population attributable fraction;Prevention and control;Principal component analysis;Stomach neoplasms
metadata.dc.subject.mesh: Adenocarcinoma
Aged, 80 and over
Case-Control Studies
Feeding Behavior
Middle Aged
Risk Factors
Stomach Neoplasms
Young Adult
Issue Date: 14-Nov-2017
Abstract: The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology. MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age. Risk according to tumor site (cardia, non-cardia) and morphology (intestinal/diffuse) was evaluated using multinomial regression models. A high adherence to the Western pattern increased gastric adenocarcinoma risk [odds ratiofourth_vs._first_quartile (95% confidence interval), 2.09 (1.31; 3.33)] even at low levels [odds ratiosecond_vs._first_quartile (95% confidence interval), 1.63 (1.05; 2.52)]. High adherence to the Mediterranean dietary pattern could prevent gastric adenocarcinoma [odds ratiofourth_vs._first_quartile (95% confidence interval), 0.53 (0.34; 0.82)]. Although no significant heterogeneity of effects was observed, the harmful effect of the Western pattern was stronger among older participants and for non-cardia adenocarcinomas, whereas the protective effect of the Mediterranean pattern was only observed among younger participants and for non-cardia tumors. Decreasing the consumption of fatty and sugary products and of red and processed meat in favor of an increase in the intake of fruits, vegetables, legumes, olive oil, nuts, and fish might prevent gastric adenocarcinoma.
metadata.dc.identifier.doi: 10.1007/s10120-017-0774-x
Appears in Collections:Producción 2020

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