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Title: The role of exosomes on colorectal cancer: A review.
Authors: Ruiz-López, Lidia
Blancas, Isabel
Garrido, José M
Mut-Salud, Nuria
Moya-Jódar, Marta
Osuna, Antonio
Rodríguez-Serrano, Fernando
Keywords: biomarkers;colorectal cancer;exosomes;intercellular communication;oncogenic transformation
metadata.dc.subject.mesh: Biomarkers, Tumor
Colorectal Neoplasms
Disease Progression
Drug Resistance, Neoplasm
Neoplasm Proteins
Protein Transport
RNA, Neoplasm
Issue Date: 19-Feb-2018
Abstract: Exosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly because of their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance, and metastasis. The role of the exosomes in these processes involves the transfer of proteins, RNAs, or mutant versions of proto-oncogenes to the target cells. In recent years, great efforts have been made to identify useful biomarkers in CRC exosomes for diagnosis, prediction of prognosis, and treatment response. This review focuses on recent studies on CRC exosomes, considering isolation, cargo, biomarkers, and the effects of exosomes on the development and progression of CRC, including resistance to antitumor therapy.
metadata.dc.identifier.doi: 10.1111/jgh.14049
Appears in Collections:Producción 2020

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