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Title: Leptin action in normal and pathological pregnancies.
Authors: Pérez-Pérez, Antonio
Toro, Ayelén
Vilariño-García, Teresa
Maymó, Julieta
Guadix, Pilar
Dueñas, José L
Fernández-Sánchez, Manuel
Varone, Cecilia
Sánchez-Margalet, Víctor
Keywords: gestational diabetes;growth restriction;leptin;placenta;polycystic ovary syndrome;pre-eclampsia;recurrent miscarriage;reproduction
metadata.dc.subject.mesh: Adipose Tissue
Immunologic Factors
Pregnancy Complications
Issue Date: 21-Nov-2017
Abstract: Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
metadata.dc.identifier.doi: 10.1111/jcmm.13369
Appears in Collections:Instituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)

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