Please use this identifier to cite or link to this item:
Title: Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.
Authors: Plaza-Díaz, Julio
Ruiz-Ojeda, Francisco Javier
Gil-Campos, Mercedes
Gil, Angel
Keywords: immune system;intestinal microbiota;mechanism of action;pediatric gastrointestinal infection;probiotics
metadata.dc.subject.mesh: Age Factors
Child, Preschool
Gastrointestinal Microbiome
Host-Pathogen Interactions
Intestinal Diseases
Treatment Outcome
Issue Date: 5-Jan-2018
Abstract: The pediatric population is continually at risk of developing infectious and inflammatory diseases. The treatment for infections, particularly gastrointestinal conditions, focuses on oral or intravenous rehydration, nutritional support and, in certain case, antibiotics. Over the past decade, the probiotics and synbiotics administration for the prevention and treatment of different acute and chronic infectious diseases has dramatically increased. Probiotic microorganisms are primarily used as treatments because they can stimulate changes in the intestinal microbial ecosystem and improve the immunological status of the host. The beneficial impact of probiotics is mediated by different mechanisms. These mechanisms include the probiotics' capacity to increase the intestinal barrier function, to prevent bacterial transferation and to modulate inflammation through immune receptor cascade signaling, as well as their ability to regulate the expression of selected host intestinal genes. Nevertheless, with respect to pediatric intestinal diseases, information pertaining to these key mechanisms of action is scarce, particularly for immune-mediated mechanisms of action. In the present work, we review the biochemical and molecular mechanisms of action of probiotics and synbiotics that affect the immune system.
metadata.dc.identifier.doi: 10.3390/nu10010042
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC5793270.pdf1,3 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons