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Title: Continued propagation of the CRF19_cpx variant among HIV-positive MSM patients in Spain.
Authors: Pérez-Parra, S
Álvarez, M
Fernandez-Caballero, J A
Pérez, A B
Santos, J
Bisbal, O
Aguilera, A
Rivero, M
García-Fraile, L
García, F
metadata.dc.subject.mesh: Adult
Aspartate Aminotransferases
CD4 Lymphocyte Count
Cluster Analysis
Disease Transmission, Infectious
HIV Infections
Homosexuality, Male
Middle Aged
Molecular Epidemiology
pol Gene Products, Human Immunodeficiency Virus
Issue Date: 2018
Abstract: The HIV-1 CRF19_cpx genetic form has been recently associated with greater pathogenicity. We used CoRIS, a national cohort of 31 reference hospitals in Spain, to investigate the current epidemiological situation of this variant in Spain. We analysed 4734 naive HIV-1-positive patients diagnosed during the 2007-15 period with an available pol gene sequence in the CoRIS resistance database. HIV-1 CRF19_cpx was ascribed through REGA3.0 and confirmed by a phylogenetic analysis. We analysed the presence of the transmission clusters of HIV-1 CRF19_cpx by maximum likelihood [with the randomized accelerated maximum likelihood (RAxML) program] and the time to the most recent common ancestor using Bayesian inference (BEAST, v. 1.7.5). Nineteen patients were infected with CRF19_cpx: all were male, they had a mean age of 42.9 years (95% CI: 36.4-52.5 years), the majority were MSM [n = 18 (95%)] and of Spanish nationality [n = 16 (84.2%)] and they had high CD4+ T cell counts (∼415 cells/mm3). Fifteen patients were grouped into four different transmission clusters: two clusters (two patients each) grouped the patients from Valencia and another cluster grouped one patient from Madrid and another from Seville. We found a larger cluster that grouped nine patients from southern Spain (Malaga and Seville), of which six presented mutation G190A. We estimated the origin of all the transmission clusters to take place between 2009 and 2010. We demonstrate that this variant has spread in Spain in recent years among young HIV-positive MSM and we note a recent expansion in southern Spain in patients who carry mutation G190A. We alert healthcare managers to enhance preventive measures to prevent the continuous spread of HIV-1 CRF19_cpx.
metadata.dc.identifier.doi: 10.1093/jac/dkx474
Appears in Collections:Producción 2020

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