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Title: Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects.
Authors: Soriguer, Federico
Gutiérrez-Repiso, Carolina
Rubio-Martin, Elehazara
Linares, Francisca
Cardona, Isabel
López-Ojeda, Jaime
Pacheco, Marta
González-Romero, Stella
Garriga, Maria J.
Velasco, Ines
Santiago, Piedad
García-Fuentes, Eduardo
metadata.dc.contributor.authoraffiliation: [Soriguer,F; González-Romero,S; García-Fuentes,E] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Soriguer,F; Rubio-Martin,E] CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. [Gutiérrez-Repiso,C; Linares,F; Cardona,I; García-Fuentes,E] Fundación IMABIS, Málaga, Spain. [López-Ojeda,J; Pacheco, M] Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Garriga, MJ] Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Velasco,I] Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. [García-Fuentes,E] CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga, Spain.
Keywords: Iodine;Thyroid function;Urinary iodine;Antioxidants;Mujeres Embarazadas;Adulto;Marcadores biológicos;Estrés Oxidativo;Inflamación;Proteínas de fase aguda
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Medical Subject Headings::Named Groups::Persons::Women::Pregnant Women
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteins
Issue Date: Jun-2011
Publisher: Cambridge University Press
Citation: Soriguer F, Gutiérrez-Repiso C, Rubio-Martin E, Linares F, Cardona I, López-Ojeda J, et al. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. Br J Nutr. 2011;105 (12):1783-90.
Abstract: Little information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n 10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r 0·50, P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r 0·461, P = 0·018), and free triiodothyronine correlated with IL-6 (r - 0·429, P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r 0·475, P = 0·014) and ceruloplasmin (r 0·599, P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r - 0·521, P = 0·005) and ceruloplasmin (r - 0·459, P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of iodide.
metadata.dc.identifier.doi: 10.1017/S0007114510005568
ISSN: 0007-1145 (Print)
1475-2662 (Online)
Appears in Collections:01- Artículos - AGS Norte de Huelva
01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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