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dc.contributor.authorSoriguer, Federico-
dc.contributor.authorGutiérrez-Repiso, Carolina-
dc.contributor.authorRubio-Martin, Elehazara-
dc.contributor.authorLinares, Francisca-
dc.contributor.authorCardona, Isabel-
dc.contributor.authorLópez-Ojeda, Jaime-
dc.contributor.authorPacheco, Marta-
dc.contributor.authorGonzález-Romero, Stella-
dc.contributor.authorGarriga, Maria J.-
dc.contributor.authorVelasco, Ines-
dc.contributor.authorSantiago, Piedad-
dc.contributor.authorGarcía-Fuentes, Eduardo-
dc.identifier.citationSoriguer F, Gutiérrez-Repiso C, Rubio-Martin E, Linares F, Cardona I, López-Ojeda J, et al. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. Br J Nutr. 2011;105 (12)
dc.identifier.issn0007-1145 (Print)-
dc.identifier.issn1475-2662 (Online)-
dc.description.abstractLittle information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n 10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r 0·50, P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r 0·461, P = 0·018), and free triiodothyronine correlated with IL-6 (r - 0·429, P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r 0·475, P = 0·014) and ceruloplasmin (r 0·599, P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r - 0·521, P = 0·005) and ceruloplasmin (r - 0·459, P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of
dc.description.sponsorshipThe present study was supported in part by grants from the Instituto de Salud Carlos III (CP04/00133). CIBER FisiopatologÍa de la Obesidad y NutriciÓn (CIBEROBN) and CIBER de Diabetes y Enfermedades MetabÓlicas Asociadas (CIBERDEM)are ISCIII
dc.publisherCambridge University Presses
dc.relation.ispartofBritish Journal of Nutritiones
dc.subjectThyroid functiones
dc.subjectUrinary iodinees
dc.subjectMujeres Embarazadases
dc.subjectMarcadores biológicoses
dc.subjectEstrés Oxidativoes
dc.subjectProteínas de fase agudaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodinees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Women::Pregnant Womenes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteinses
dc.titleIodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory
dc.rights.accessRightsAcceso abiertoes
dc.contributor.authoraffiliation[Soriguer,F; González-Romero,S; García-Fuentes,E] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Soriguer,F; Rubio-Martin,E] CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. [Gutiérrez-Repiso,C; Linares,F; Cardona,I; García-Fuentes,E] Fundación IMABIS, Málaga, Spain. [López-Ojeda,J; Pacheco, M] Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Garriga, MJ] Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Velasco,I] Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. [García-Fuentes,E] CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga,
Appears in Collections:01- Artículos - AGS Norte de Huelva
01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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