Please use this identifier to cite or link to this item:
Title: Systematic review of the efficacy of statins for the treatment of Alzheimer's disease.
Authors: Mejías-Trueba, Marta
Pérez-Moreno, María Antonia
Fernández-Arche, María Ángeles
Keywords: Alzheimer's disease;efficacy;statins;systematic review
metadata.dc.subject.mesh: Alzheimer Disease
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Treatment Outcome
Issue Date: 2018
Abstract: Alzheimer's disease (AD) is the most common type of dementia. Recent studies have assessed the possibility of using statins as treatment for AD. However, their efficacy is not clear. In this study, we collected the most relevant information about the efficacy of statins for the treatment of AD. We conducted a systematic literature search using MEDLINE, EMBASE and The Cochrane Library. We included clinical trials, meta-analyses and systematic reviews that analysed the efficacy of statins in AD. We also extracted the characteristics and efficacy results of the studies selected. Of the 304 articles identified, 13 complied with the inclusion criteria. The scientific quality of studies was high and their results indicated that there were no significant differences in the main efficacy variables between statins and placebo treatment for AD. Therefore, according to the available scientific evidence, statins have not shown an improvement in cognition and do not appear to offer significant benefits to patients with AD.
metadata.dc.identifier.doi: 10.7861/clinmedicine.18-1-54
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.