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Title: Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins.
Authors: Murciano, Carmen
Cazorla-Vázquez, Salvador
Gutiérrez, Javier
Hijano, Juan Antonio
Ruiz-Sánchez, Josefa
Mesa-Almagro, Laura
Martín-Reyes, Flores
Fernández, Tahía Diana
Marí-Beffa, Manuel
Keywords: knck5b;actinopterygii;euteleostei;evo-devo;fibroblast growth factor receptor 1;fin regeneration;inter-ray
metadata.dc.subject.mesh: Animal Fins
Animals, Genetically Modified
Cell Movement
Gene Expression
Hedgehog Proteins
Potassium Channels, Tandem Pore Domain
Receptor, Fibroblast Growth Factor, Type 1
Zebrafish Proteins
Issue Date: 14-Feb-2018
Abstract: The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signalling processes which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the fin pattern along the proximodistal axis brings with it several well-known developmental regulators, the mechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing the zebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species, we hypothesized a connection between specific inter-ray regulatory mechanisms and the morphological variability of inter-ray membranes found in nature. To tackle these issues, both cellular and molecular approaches have been adopted and our results suggest the existence of two distinguishable inter-ray areas in the zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cell membrane potassium channel kcnk5b, the fibroblast growth factor receptor 1 and the sonic hedgehog pathway to the control of several cell functions involved in inter-ray wound healing or dorsoventral regeneration of the zebrafish caudal fin. This ray-dependent regulation controls cell migration, cell-type patterning and gene expression. The possibility that modifications of these mechanisms are responsible for phenotypic variations found in euteleostean species, is discussed.
metadata.dc.identifier.doi: 10.1111/joa.12785
Appears in Collections:Producción 2020

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