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Title: Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.
Authors: de Llano, Luis Pérez
Cosío, Borja G
Iglesias, Amanda
de Las Cuevas, Natividad
Soler-Cataluña, Juan Jose
Izquierdo, Jose Luis
López-Campos, Jose Luis
Calero, Carmen
Plaza, Vicente
Miravitlles, Marc
Torrego, Alfons
Martinez-Moragon, Eva
Soriano, Joan B
Viña, Antolin Lopez
Bobolea, Irina
Keywords: COPD mechanisms;IL-13;asthma mechanisms;inflammatory cytokines;network analysis;overlap
metadata.dc.subject.mesh: Adult
Cell Adhesion Molecules
Cross-Sectional Studies
Discriminant Analysis
Forced Expiratory Volume
Inflammation Mediators
Middle Aged
Neural Networks, Computer
Pulmonary Disease, Chronic Obstructive
Th2 Cells
Tumor Necrosis Factor-alpha
Vital Capacity
Issue Date: 12-Feb-2018
Abstract: The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. Determining systemic mediators may help clarify the nature of inflammation in patients with ACO. We aimed at investigating the role and interaction of common markers of systemic inflammation (IL-6, IL-8, and tumor necrosis factor-α), Th2-related markers (periostin, IL-5, and IL-13), and IL-17 in asthma, COPD, and ACO. This is a cross-sectional study of patients aged ≥40 years with a post-bronchodilator forced expiratory volume in the first second/forced vital capacity 10 pack-years in a patient with a previous diagnosis of asthma or by the presence of eosinophilia in a patient with a previous diagnosis of COPD. Clinical, functional, and inflammatory parameters were compared between categories using discriminant and network analysis. In total, 109 ACO, 89 COPD, and 94 asthma patients were included. Serum levels (median [interquartile range]) of IL-5 were higher in asthma patients than in COPD patients (2.09 [0.61-3.57] vs 1.11 [0.12-2.42] pg/mL, respectively; p=0.03), and IL-8 levels (median [interquartile range]) were higher in COPD patients than in asthma patients (9.45 [6.61-13.12] vs 7.03 [4.69-10.44] pg/mL, respectively; p Asthma and COPD are two different inflammatory conditions that may overlap in some patients, leading to a mixed inflammatory pattern. IL-13 could be central to the regulation of inflammation in these conditions.
metadata.dc.identifier.doi: 10.2147/COPD.S153694
Appears in Collections:Producción 2020

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