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Título : Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans.
Autor : Fagundo, Ana B
Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Pastor, Antoni
Casanueva, Felipe F
Granero, Roser
Baños, Rosa
Botella, Cristina
Pino-Gutiérrez, Amparo del
Fernández-Real, José M
Fernández-García, José C
Frühbeck, Gema
Gómez-Ambrosi, Javier
Menchón, José M
Moragrega, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones, Francisco J
Fernández-Aranda, Fernando
Filiación: [Fagundo,AB; Jiménez-Murcia,S; Pino-Gutiérrez,A del; Menchón,JM; Fernández-Aranda,F] Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain. [Fagundo,AB; Torre,R de la; Jiménez-Murcia,S; Agüera,Z; Casanueva,FF; Granero,R; Baños,R; Botella,C; Fernández-Real,JM; Fernández-García,JC; Frühbeck,G; Gómez-Ambrosi,J; Moragrega,I; Rodríguez,R; Tinahones,FJ; Fernández-Aranda,F] CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Barcelona, Spain. [Torre,R de la; Pastor,A] Human Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. [Jiménez-Murcia,S; Menchón,JM; Fernández-Aranda,F] Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain. [Pastor,A] Department of Pharmacology, School of Medicine, Universitat Autònoma de Barcelona, Spain. [Casanueva,FF] Endocrine Division, Complejo Hospitalario U. de Santiago, Santiago de Compostela University, Spain. [Granero,R; Tárrega,S] Departament de Psicobiologia i Metodologia, Universitat Autònoma de Barcelona, Spain. [Baños,R] Department of Personality, Evaluation and Psychological Treatment of the University of Valencia, Spain. [Botella,C; Moragrega,I] Department of Basic Psychology, Clinic and Psychobiology of the University Jaume I, Castelló, Spain. [Pino-Gutiérrez,A del] Nursing Department of Public Health, Maternal and Child Health the Nursing School of the University of Barcelona, Spain. [Fernández-Real,JM; Rodríguez,R] Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, Spain. [Fernández-García,JC; Tinahones,FJ] Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Frühbeck,G; Gómez-Ambrosi,J] Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain. [Menchón,JM] CIBER Salud Mental (CIBERsam), Instituto Salud Carlos III, Barcelona, Spain.
Palabras clave : Endocannabinoides
Receptores de cannabinoides
Ácidos araquidónicos
Sistema nervioso central
Enfermedades neurodegenerativas
Función ejecutiva
Pruebas neuropsicológicas
Abuso de marihuana
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Arachidonic Acids
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System
Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Executive Function
Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Marijuana Abuse
Fecha de publicación : 19-Jun-2013
Editorial : Public Library of Science
Cita Bibliográfica: Fagundo AB, de la Torre R, Jiménez-Murcia S, Agüera Z, Pastor A, Casanueva FF, et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. PLoS ONE. 2013; 8(6):e66387
Abstract: Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = -.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = -.17) or AEA (r = -.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.
Descripción : JOURNAL ARTICLE;
Versión del editor :
DOI: 10.1371/journal.pone.0066387
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria

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