Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1298
Título : Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study
Autor : Langenberg, Claudia
Sharp, Stephen J
Schulze, Matthias B
Rolandsson, Olov
Overvad, Kim
Forouhi, Nita G
Spranger, Joachim
Drogan, Dagmar
Huerta, José María
Arriola, Larraitz
de Lauzon-Guillan, Blandine
Tormo, Maria-Jose
Ardanaz, Eva
Balkau, Beverley
Beulens, Joline W J
Boeing, Heiner
Bueno-de-Mesquita, H Bas
Clavel-Chapelon, Françoise
Crowe, Francesca L
Franks, Paul W
Gonzalez, Carlos A
Grioni, Sara
Halkjaer, Jytte
Hallmans, Goran
Kaaks, Rudolf
Kerrison, Nicola D
Key, Timothy J
Khaw, Kay Tee
Mattiello, Amalia
Nilsson, Peter
Norat, Teresa
Palla, Luigi
Palli, Domenico
Panico, Salvatore
Quirós, J Ramón
Romaguera, Dora
Romieu, Isabelle
Sacerdote, Carlotta
Sánchez, María-José
Slimani, Nadia
Sluijs, Ivonne
Spijkerman, Annemieke M W
Teucher, Birgit
Tjonneland, Anne
Tumino, Rosario
van der A, Daphne L
van der Schouw, Yvonne T
Feskens, Edith J M
Riboli, Elio
Wareham, Nicholas J
Schulze, Matthias B.
Filiación: [Langenberg,C; Sharp,SJ; Forouhi,NG; Kerrison,ND; Palla,L; Wareham,NJ] MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom. [Schulze,MB] Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur-Scheunert-Allee, Nuthetal, Germany. [Rolandsson,O; Hallmans,G] Department of Public Health and Clinical Medicine, Umea University, Norrlands Universitetsjukhus, Umea, Sweden. [Overvad,K] Department of Epidemiology, School of Public Health, Aarhus C, Denmark. [Spranger.J] Charité-Universitatsmedizin Berlin, Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany. [Drogan,D; Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.[Arriola,L; Tormo,MJ] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Huerta,JM; Arriola,L; Tormo,MJ; Ardanaz,E; Sánchez,MJ] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pu´ blica), Madrid, Spain . [Arriola,L] Public Health Division of Gipuzkoa, Basque Government, San Sebastian, Spain. Instituto BIO-Donostia, Hospital Donostia, Donostia, Basque Country. [Lauzon-Guillan,B; Balkau,B] INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018: Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif Cedex, France. University Paris, Villejuif Cedex, France. [Ardanaz,E] Navarre Public Health Institute, Pamplona, Navarra, Spain. [Beulens,JWJ; Sluijs,I; Schouw,T] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Clavel-Chapelon,F] INSERM, CESP Centre for Research in Epidemiology and Population Health,U1018: Nutrition, Hormones and Women’s Health, IGR, Villejuif Cedex, France. [Crowe,FL; Key,TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford,Richard Doll Building, Roosevelt Drive, Oxford, United Kingdom. [Grioni,S] Fondazione IRCCS Istituto Nazionale Tumori Milan, Milan, Italy. [Halkjaer,J; Tjonneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Kerrison,ND; Teucher,B] German Cancer Research Centre, Heidelberg, Germany. [Khaw,KT] Department of Public Health and Primary Care, University of Cambridge Addenbrooke’s Hospital, Cambridge, United Kingdom. [Mattiello,A] Department of Clinical and Experimental Medicine Federico II University, Naples, Italy. [Nilsson,P; Panico,S] University of Lund, Department of Clinical Sciences Medicine, University Hospital Scania, Malmo, Sweden. [Norat,T; Romaguera,D; Riboli,E] Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. [Palli,D] Molecular and Nutritional Epidemiology Unit, ISPO Ponte Nuovo, Florence, Italy. [Quirós, JR] Public Health Directorate, Oviedo, Spain. [Romieu,I; Slimani,N] International Agency for Research on Cancer, Lyon Cedex, France. [Sacerdote,C] Center for Cancer Prevention (CPO-Piemonte), Torino, Italy. Human Genetics Foundation (HuGeF), Torino, Italy. [Sánchez,MJ] Andalusian School of Public Health, Granada, Spain. [Spijkerman,AMW; A Daphne,L] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Tumino,R] Cancer Registry and Histopathology Unit, ‘‘Civile - M.P. Arezzo’’ Hospital, Dante Ragusa, Italy. [Feskens,EJM] Division of Human Nutrition - Section Nutrition and Epidemiology, University of Wageningen, Wageningen, The Netherlands. [Franks,PW] Department of Clinical Sciences, Clinical Research Center, Ska°ne University Hospital, Lund University, Malmö , Sweden. [Bueno-de-Mesquita,HB] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
Grupo de Investigación: The InterAct Consortium
Palabras clave : Antropometría
Índice de Masa Corporal
Diabetes Mellitus Tipo 2
Estudios de Cohortes
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Anthropometry
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference
Medical Subject Headings::Geographicals::Geographic Locations::Europe
Fecha de publicación : 5-Jun-2012
Editorial : Public Library of Science
Cita Bibliográfica: Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, et al. Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 2012; 9(6) e1001230
Abstract: BACKGROUND Waist circumference (WC) is a simple and reliable measure of fat distribution that may add to the prediction of type 2 diabetes (T2D), but previous studies have been too small to reliably quantify the relative and absolute risk of future diabetes by WC at different levels of body mass index (BMI). METHODS AND FINDINGS The prospective InterAct case-cohort study was conducted in 26 centres in eight European countries and consists of 12,403 incident T2D cases and a stratified subcohort of 16,154 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. We used Prentice-weighted Cox regression and random effects meta-analysis methods to estimate hazard ratios for T2D. Kaplan-Meier estimates of the cumulative incidence of T2D were calculated. BMI and WC were each independently associated with T2D, with WC being a stronger risk factor in women than in men. Risk increased across groups defined by BMI and WC; compared to low normal weight individuals (BMI 18.5-22.4 kg/m(2)) with a low WC (<94/80 cm in men/women), the hazard ratio of T2D was 22.0 (95% confidence interval 14.3; 33.8) in men and 31.8 (25.2; 40.2) in women with grade 2 obesity (BMI≥35 kg/m(2)) and a high WC (>102/88 cm). Among the large group of overweight individuals, WC measurement was highly informative and facilitated the identification of a subgroup of overweight people with high WC whose 10-y T2D cumulative incidence (men, 70 per 1,000 person-years; women, 44 per 1,000 person-years) was comparable to that of the obese group (50-103 per 1,000 person-years in men and 28-74 per 1,000 person-years in women). CONCLUSIONS WC is independently and strongly associated with T2D, particularly in women, and should be more widely measured for risk stratification. If targeted measurement is necessary for reasons of resource scarcity, measuring WC in overweight individuals may be an effective strategy, since it identifies a high-risk subgroup of individuals who could benefit from individualised preventive action.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1298
Versión del editor : http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001230
DOI: 10.1371/journal.pmed.1001230
ISSN : 1549-1676 (Online)
1549-1277 (Print)
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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