Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1304
Título : Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic patients.
Autor : Giner, Mercè
Montoya, Mª José
Vázquez, Mª Angeles
Miranda, Cristina
Pérez-Cano, Ramón
Filiación: [Giner,M; Vázquez,MA; Pérez-Cano,R] Bone Metabolism Unit, Internal Medicine, “Virgen Macarena” University Hospital, Sevilla, Spain. [Giner,M; Montoya,MJ; Vázquez,MA; Pérez-Cano,R] Medicine Department, University of Seville, Seville, Spain.
Palabras clave : Human bone
Osteoporosis
Osteogenesis
Apoptosis
Microstructural
Densidad Ósea
Fracturas de cadera
Ancianos de 80 o más años
Reacción en cadena de la polimerasa en tiempo real
Reacción en cadena de la polimerasa por transcriptasa inversa
MeSH: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Biomechanics
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation
Medical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Hip Fractures
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Osteoarthritis::Osteoarthritis, Hip
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Musculoskeletal Development::Bone Development::Osteogenesis
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Metabolic::Osteoporosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Reverse Transcriptase Polymerase Chain Reaction
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Fecha de publicación : 25-Jan-2013
Editorial : BioMed Central
Cita Bibliográfica: Giner M, Montoya MJ, Vázquez MA, Miranda C, Pérez-Cano R. Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic patients. BMC Musculoskelet Disord.2013 Jan 25; 14:41
Abstract: BACKGROUND Osteoporosis is a metabolic disorder characterized by a reduction in bone mass and deterioration in the microarchitectural structure of the bone, leading to a higher risk for spontaneous and fragility fractures.The main aim was to study the differences between human bone from osteoporotic and osteoarthritic patients about gene expression (osteogenesis and apoptosis), bone mineral density, microstructural and biomechanic parameters. METHODS We analyzed data from 12 subjects: 6 with osteoporotic hip fracture (OP) and 6 with hip osteoarthritis (OA), as the control group. All subjects underwent medical history, analytical determinations, densitometry, histomorphometric and biochemical study. The expression of 86 genes of osteogenesis and 86 genes of apoptosis was studied in pool of bone samples from patients with OP and OA by PCR array. RESULTS We observed that most of the genes of apoptosis and osteogenesis show a decrease in gene expression in the osteoporotic group in comparison with the osteoarthritic group. The histomorphometric study shows a lower bone quality in the group of patients with hip fractures compared to the osteoarthritic group. CONCLUSIONS The bone tissue of osteoporotic fracture patients is more fragile than the bone of OA patients. Our results showed an osteoporotic bone with a lower capacities for differentiation and osteoblastic activity as well as a lower rate of apoptosis than osteoarthritic bone. These results are related with structural and biochemical parameters.
Descripción : Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1304
Versión del editor : http://www.biomedcentral.com/1471-2474/14/41/abstract
DOI: 10.1186/1471-2474-14-41
ISSN : 1471-2474 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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