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Title: Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.
Authors: Rodríguez, Víctor
Martín, Jesús
Sarmiento-Vizcaíno, Aida
de la Cruz, Mercedes
García, Luis A
Blanco, Gloria
Reyes, Fernando
Keywords: Cantabrian Sea;Streptomyces cyaneofuscatus;anthracimycin;deep-sea actinobacteria
metadata.dc.subject.mesh: Anti-Bacterial Agents
Aquatic Organisms
Gram-Positive Bacteria
Microbial Sensitivity Tests
Issue Date: 25-Oct-2018
Abstract: The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
metadata.dc.identifier.doi: 10.3390/md16110406
Appears in Collections:Fundación Pública Andaluza Progreso y Salud

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