Please use this identifier to cite or link to this item:
Title: Long-term consequences of uninephrectomy in male and female rats.
Authors: Rodríguez-Gómez, Isabel
Wangensteen, Rosemary
Pérez-Abud, Rocío
Quesada, Andrés
Moral, Raimundo G Del
Osuna, Antonio
O'Valle, Francisco
Luna, Juan de Dios
Vargas, Félix
metadata.dc.contributor.authoraffiliation: [Rodríguez-Gómez,I; Vargas,F] Departamento de Fisiología, Facultad de Medicina, Granada, Spain. [Luna, J de D] Departamento de Bioestadística, Facultad de Medicina, Granada, Spain. [Pérez-Abud,R; Osuna,A] Servicio de Nefrología, Unidad Experimental, Hospital Virgen de las Nieves, Granada, Spain. [Wangensteen,R; Quesada,A] Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain. [Moral, RG del; O’Valle, F] Departamento de Anatomía Patológica e Instituto de Biomedicina Regenerativa, Facultad de Medicina, Granada, Spain.
Keywords: Uninephrectomy;renal sodium handling;renal injury;blood pressure;rat;Presión Arterial;Femenino;Riñón;Masculino;Nefrectomía;Estrés Oxidativo;Proteinuria;Ratas;Ratas Wistar;Factores Sexuales;Sodio
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Kidney
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Urogenital Surgical Procedures::Urologic Surgical Procedures::Nephrectomy
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Proteinuria
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Sex Factors
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Metals::Metals, Alkali::Sodium
Medical Subject Headings::Organisms::Eukaryota::Animals
Issue Date: Dec-2012
Publisher: American Heart Association
Citation: Rodríguez-Gómez I, Wangensteen R, Pérez-Abud R, Quesada A, Del Moral RG, Osuna A, et al. Long-term consequences of uninephrectomy in male and female rats. Hypertension. 2012 ; 60(6):1458-63
Abstract: We investigated the effects of uninephrectomy (UNX) in 6-week-old male and female rats on blood pressure (BP), renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery, studying control sham-operated and UNX-operated rats at 6, 12, and 18 months postsurgery, evaluating their renal sodium handling, BP, urinary isoprostanes, N-acetyl-β-D-glucosaminidase, and proteinuria before and after a 2-week high-salt intake period. At 18 months, plasma variables were measured and kidney samples were taken for the analysis of renal morphology and tissue variables. BP was increased at 6 months in male UNX rats versus controls and at 12 and 18 months in both male and female UNX rats and was increased in male versus female UNX groups at 18 months. UNX did not affect water and sodium excretion under basal conditions and after the different test in male and female rats at different ages. However, the renal function curve was shifted to the right in both male and female UNX rats. High-salt intake increased BP in both UNX groups at 6, 12, and 18 months and in the female control group at 18 months, and it increased proteinuria, N-acetyl-β-D-glucosaminidase, and isoprostanes in both UNX groups throughout the study. Renal lesions at 18 months were more severe in male versus female UNX rats. In summary, long-term UNX increased the BP, creatinine, proteinuria, pathological signs of renal injury, and salt sensitivity. Earlier BP elevation was observed and morphological lesions were more severe in male than in female UNX rats.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1161/HYPERTENSION AHA.112.198499
ISSN: 1524-4563 (Online)
0194-911X (Print)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

Files in This Item:
File Description SizeFormat 
Rodríguez-Gómez_Long-Term.pdf988,41 kBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons