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Title: Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review).
Authors: Martino, Alessandro
Sainz, Juan
Buda, Gabriele
Jamroziak, Krzysztof
Reis, Rui Manuel
García-Sanz, Ramón
Jurado, Manuel
Ríos, Rafael
Szemraj-Rogucka, Zofia
Marques, Herlander
Lesueur, Fabienne
Moreno, Victor
Orciuolo, Enrico
Gemignani, Federica
Landi, Stefano
Rossi, Anna Maria
Dumontet, Charles
Petrini, Mario
Campa, Daniele
Canzian, Federico
metadata.dc.contributor.authoraffiliation: [Martino,A; Campa,D; Canzian,F] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Sainz,J; Jurado,M; Ríos,R] Genomic Oncology Area, Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENYO), Granada. Department of Hematology, Virgen de las Nieves University Hospital, Granada, Spain. [Buda,G; Orciuolo,E; Petrini,M] Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, University of Pisa, Pisa, Italy. [Jamroziak,K; Szemraj-Rogucka,Z] Department of Hematology, Medical University of Lodz, Lodz, Poland. [Reis,RM; Marques,H] Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. [García-Sanz,R] University Hospital of Salamanca, Universidad de Salamanca-Centro de Investigación del Cáncer, Salamanca, Spain. [Lesueur,F] Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France. [Moreno,V] IDIBELL-Catalan Institute of Oncology, CIBERESP and University of Barcelona, Barcelona, Spain. [Gemignani,F; Landi,S; Rossi,AM] Department of Biology, Section of Genetics, University of Pisa, Pisa, Italy. [Dumontet,C] INSERM UMR 1052/CNRS 5286, Laboratoire de Cytologie Analytique, Faculté de Medecine Rockefeller, Université Claude Bernard Lyon I, Lyon, France. [Reis,RM] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
Keywords: IMMEnSE consortium,;Multiple myeloma;SNPs;Genetic susceptibility;Hharmacogenetics;Humanos;Variación Genética;Farmacogenética;Factores de Riesg0;Mieloma Múltiple;Epidemiología Molecular
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Pharmacogenetics
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease
Issue Date: Mar-2012
Publisher: Spandidos Publications
Citation: Martino A, Sainz J, Buda G, Jamroziak K, Reis RM, García-Sanz R, et al. Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review). Int. J. Oncol. 2012; 40(3):625-38
Abstract: There is strong evidence suggesting the presence of a genetic component in the aetiology of multiple myeloma (MM). However no genetic risk factors have been unequivocally established so far. To further our understanding of the genetic determinants of MM risk, a promising strategy is to collect a large set of patients in a consortium, as successfully done for other cancers. In this article, we review the main findings in the genetic susceptibility and pharmacogenetics of MM and present the strategy of the IMMEnSE (International Multiple Myeloma rESEarch) consortium in contributing to determine the role of genetic variation in pharmacogenetics and in MM risk.
Description: Journal Article; Research Support, Non-U.S. Gov't; Review;
metadata.dc.identifier.doi: 10.3892/ijo.2011.1284
ISSN: 1791-2423 (Online)
1019-6439 (Print)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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